ORM1 MEDIATES OSTEOBLAST/OSTEOCLAST CROSSTALK IN ADOLESCENT IDIOPATHIC SCOLIOSIS VIA RANKL/OPG RATIO ALTERATION

ORM1 mediates osteoblast/osteoclast crosstalk in adolescent idiopathic scoliosis via RANKL/OPG ratio alteration

Adolescent idiopathic scoliosis (AIS), a complex early-onset three-dimensional spinal deformity, remains etiologically ambiguous despite extensive ongoing investigations.Currently, braces and surgeries are primary treatments of AIS, which come with inherent risks and costs.Therefore, there is an urgent need for biotherapeutic targets for AIS.Using

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Malignant melanoma of the oral cavity: Report of two cases

Primary malignant melanoma is a rare and aggressive neoplasm that Mens originates from the proliferation of melanocytes.Although, it comprises 1.3% of all cancers, malignant melanoma of the oral cavity accounts for only 0.2-8% of all reported melanomas and occurs approximately 4 times more frequently in the oral mucosa of the upper jaw, usually on

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